In silico prediction of blood-brain barrier permeation.

A fragment-based approach for the in silico prediction of blood-brain barrier permeation

In Silico Design and Verification of LAMP-BDNF Chimeric Protein for Presentation of BDNF on the Surface of Exosomes for Drug Delivery Through Blood-Brain Barrier

Background and purpose: The mature form of brain-derived neurotrophic factor (BDNF) binds to BDNF/NT-3 growth factors receptor (Trk-B). This binding leads to activation of Ras–MAPK pathway which is integrated with cell growth and proliferation. The BDNF deficiency is correlated with various diseases and affects aging and miscellaneous. In the present study we aimed to design a chimeric LAMP-BDN...

Prediction of In Silico ADME Properties of 1,2-O-Isopropylidene Aldohexose Derivatives

Retention behavior of molecules mostly depends on their chemical structure. Retention data of biologically active molecules could be an indirect relationship between their structure and biological or pharmacological activity, since the molecular structure affects their behavior in all pharmacokinetic stages. In the present paper, retention parameters (RM0) of biologically active 1,2-O-isopropyl...

Prediction of In Silico ADME Properties of 1,2-O-Isopropylidene Aldohexose Derivatives

Retention behavior of molecules mostly depends on their chemical structure. Retention data of biologically active molecules could be an indirect relationship between their structure and biological or pharmacological activity, since the molecular structure affects their behavior in all pharmacokinetic stages. In the present paper, retention parameters (RM0) of biologically active 1,2-O-isopropyl...

Correction to: In Silico Design and Verification of LAMP-BDNF Chimeric Protein for Presentation of BDNF on the Surface of Exosomes for Drug Delivery Through Blood-Brain Barrier

In the article published in volume 32, issue 215, 2022,http://jmums.mazums.ac.ir/article-1-17695-fa.html the affilifations of Naghi Shahabi Majd, Hosein Ranjbaran, and Shabanali Khodashenas were published incorrectly, which are now corrected.